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KMID : 0882420060710030328
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Korean Journal of Medicine
2006 Volume.71 No. 3 p.328 ~ p.332
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A case of chronic neutrophilic leukemia
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홍순창/Hong SC
김지훈/이정민/정준오/김윤권/김소연/이경인/Kim JH/Lee JM/Chung JO/Kim YK/Kim SY/Lee GI
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Abstract
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Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by clonal proliferation of mature neutrophils, hepatosplenomegaly, elevated leukocyte alkaline phosphatase score (ALP score) and a negative Philadelphia chromosome. To date, approximately 150 cases have been reported in the literature, including some cases presenting with a ’leukemic’ state reflected by a neutrophilic reaction. The term ’true’ CNL, recently introduced by Reilly, highlights the need for more experience with CNL cases to improve the diagnostic criteria. In Korea, about 10 cases have been reported in the literature and some of those cases did not meet the WHO diagnostic criteria for CNL. We present a typical case of CNL in a 66-year-old man who complained of general weakness and weight loss. On admission, the white blood cell count from the peripheral blood was 175,600/L with 80% segmented neutrophils. The cytogenic study was negative for the Philadelphia chromosome and had a normal karyotype.
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